The Calhoun Building is located near the corner of Sumter and Senate Streets in downtown Columbia.
From I-20 W, merge onto SC-277 S via Exit 73A toward Columbia. Stay straight to go onto Bull St. Turn right onto Gervais Street. Turn left onto Sumter Street.
From I-26 E, merge onto I-126 E via Exit 108B toward downtown Columbia. Merge onto Huger St. Turn left onto Gervais Street. Turn right onto Sumter Street.
From I-26 W, merge onto US-1 Augusta Hwy via Exit 111A toward Columbia. US-1 becomes Gervais Street. Turn right onto Sumter Street.